Fluoxetine alleviates vascular cognitive impairment by activating the Nrf2/ARE pathway via Sp1-mediated OTUD1 transcription
the Sp1-mediated upregulation of OTUD1 to activate the Nrf2/ARE pathway. This study indicates fluoxetine may have therapeutic potential for CSVD-related cognitive impairment.
Authors
- Chanjuan Chen (ORCID: https://orcid.org/0000-0002-9853-2632)
- Jingwen Hao
- Qi Wan
Institutions
- The First Hospital of Changsha (CN)
Publication Details
- Journal
- Free Radical Research
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1080/10715762.2026.2658796
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00