Real-time, non-invasive monitoring of inhalable powder dissolution using optical coherence tomography
> 0.99) for lactose powder. Differences in dissolution behaviour arising from powder properties (e.g., particle size) and hydrodynamic conditions (e.g., agitation rate) were resolved across the investigated formulations, demonstrating sensitivity to powder properties and hydrodynamic effects. Overall, the proposed method provides a robust, non-destructive framework for real-time analysis of transient and equilibrium dissolution behaviour, well suited to rapid batch-to-batch screening and dissolution studies.
Authors
- Agisilaos Kourmatzis (ORCID: https://orcid.org/0000-0003-3932-0370)
- Hak‐Kim Chan (ORCID: https://orcid.org/0000-0002-7054-3137)
- Xinyu Cai
- Taye Mekonnen (ORCID: https://orcid.org/0000-0003-3799-6553)
- Shaokoon Cheng (ORCID: https://orcid.org/0000-0002-2057-4605)
- Athiya Azeem (ORCID: https://orcid.org/0000-0003-4105-506X)
Institutions
- The University of Sydney (AU)
- Macquarie University (AU)
Publication Details
- Journal
- International Journal of Pharmaceutics
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1016/j.ijpharm.2026.126866
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Sydney
- Australian Research Council