Biogenic synthesis of bioactive zinc nanoparticles from cyanobacterial Nostoc sp. MK-7 for biomedical applications

= 55 ± 5 µg/mL). Importantly, the nanoparticles significantly reduced viability of MDA-MB-231 breast cancer cells by inducing apoptosis, as confirmed by Annexin V-FITC/PI staining and flow cytometry. Furthermore, MK-7 ZnO NPs suppressed nitric oxide production and downregulated IL-6 secretion and mRNA expression, demonstrating potent anti-inflammatory and anticancer effects. Overall, the findings highlight the successful biosynthesis of structurally stable, hexagonal MK-7 ZnO NPs with enhanced antioxidant, anti-inflammatory, anti-wrinkle, and anticancer activities. These results underscore the promising potential of MK-7 ZnO NPs as multifunctional therapeutic agents, warranting further in vivo investigations for clinical translation.

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Publication Details

Journal
Discover Nano
Published
2026-04-13
DOI
https://doi.org/10.1186/s11671-026-04549-y
Primary Topic
Nanoparticles: synthesis and applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Biogenic synthesis of bioactive zinc nanoparticles from cyanobacterial Nostoc sp. MK-7 for biomedical applications

Ji Hyang Kim, Muhammad Awais Farooqi, Sehui Kim, Muhammad Kaleem et al.
Discover Nano
Nanoparticles: synthesis and applications
article

Biogenic synthesis of bioactive zinc nanoparticles from cyanobacterial Nostoc sp. MK-7 for biomedical applications

Ji Hyang Kim, Muhammad Awais Farooqi, Sehui Kim, Muhammad Kaleem, Chul Ung Kang, Hafiz Muhammad Umer Farooqi, Chang Gu Hyun, Sungmin Bae
article en

Abstract

= 55 ± 5 µg/mL). Importantly, the nanoparticles significantly reduced viability of MDA-MB-231 breast cancer cells by inducing apoptosis, as confirmed by Annexin V-FITC/PI staining and flow cytometry. Furthermore, MK-7 ZnO NPs suppressed nitric oxide production and downregulated IL-6 secretion and mRNA expression, demonstrating potent anti-inflammatory and anticancer effects. Overall, the findings highlight the successful biosynthesis of structurally stable, hexagonal MK-7 ZnO NPs with enhanced antioxidant, anti-inflammatory, anti-wrinkle, and anticancer activities. These results underscore the promising potential of MK-7 ZnO NPs as multifunctional therapeutic agents, warranting further in vivo investigations for clinical translation.

Discover NanoVol. 21(1)
Quaid-i-Azam University (PK), Children's Hospital of Orange County (US), Hanwha Techwin (South Korea) (KR), Yonsei University (KR), Jeju National University (KR)
Ministry of Education, India
Openalex Percentile: Top 27%
Nanoparticles: synthesis and applications
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Biogenic synthesis of bioactive zinc nanoparticles from cyanobacterial Nostoc sp. MK-7 for biomedical applications — Ji Hyang Kim, Muhammad Awais Farooqi, et al. · Discover Nano (2026) | TGRS Research Map | TGRS