Biogenic synthesis of bioactive zinc nanoparticles from cyanobacterial Nostoc sp. MK-7 for biomedical applications
= 55 ± 5 µg/mL). Importantly, the nanoparticles significantly reduced viability of MDA-MB-231 breast cancer cells by inducing apoptosis, as confirmed by Annexin V-FITC/PI staining and flow cytometry. Furthermore, MK-7 ZnO NPs suppressed nitric oxide production and downregulated IL-6 secretion and mRNA expression, demonstrating potent anti-inflammatory and anticancer effects. Overall, the findings highlight the successful biosynthesis of structurally stable, hexagonal MK-7 ZnO NPs with enhanced antioxidant, anti-inflammatory, anti-wrinkle, and anticancer activities. These results underscore the promising potential of MK-7 ZnO NPs as multifunctional therapeutic agents, warranting further in vivo investigations for clinical translation.
Authors
- Ji Hyang Kim (ORCID: https://orcid.org/0000-0002-9864-9777)
- Muhammad Awais Farooqi (ORCID: https://orcid.org/0000-0002-8035-9296)
- Sehui Kim (ORCID: https://orcid.org/0000-0002-6640-3051)
- Muhammad Kaleem (ORCID: https://orcid.org/0009-0003-6548-3920)
- Chul Ung Kang
- Hafiz Muhammad Umer Farooqi (ORCID: https://orcid.org/0000-0002-1735-5911)
- Chang Gu Hyun
- Sungmin Bae
Institutions
- Quaid-i-Azam University (PK)
- Children's Hospital of Orange County (US)
- Hanwha Techwin (South Korea) (KR)
- Yonsei University (KR)
- Jeju National University (KR)
Publication Details
- Journal
- Discover Nano
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1186/s11671-026-04549-y
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, India