Generation of iVero.219-mcRTA: a doxycycline-inducible high-titer KSHV producer cell line with multicopy orf50 integration
IU/mL, without the need for HDACi. Collectively, the iVero.219-mcRTA system enables robust, high-titer KSHV production using DOX alone, providing a simplified and HDACi-independent tool that will facilitate future KSHV research.
Authors
- JlNGBO WU
- Linlin Wang (ORCID: https://orcid.org/0000-0002-7014-2149)
- Ya Xu (ORCID: https://orcid.org/0000-0003-2844-9371)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Ying Wang
Institutions
- Nankai University (CN)
- Ecologie microbienne (FR)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3389/fcimb.2026.1760149
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Tianjin City