A “one-two punch” strategy to reverse immunosuppressive metabolism and activate T-cell immunity for enhanced cancer checkpoint immunotherapy
T cell recruitment. Furthermore, the treatment exhibits a potent abscopal effect in a metastatic tumor model. This work establishes a synergistic combination strategy that disrupts tumor metabolic defenses while boosting antitumor immunity, offering a promising approach to overcome resistance to cancer immune checkpoint blockade.
Authors
- Yangyang Feng
- Peng Chang (ORCID: https://orcid.org/0000-0001-7926-7725)
- Xiaoyu Yang (ORCID: https://orcid.org/0000-0003-3437-8207)
- Chenying Wang (ORCID: https://orcid.org/0000-0002-3214-2586)
- Wenhua Zhan (ORCID: https://orcid.org/0000-0002-5795-2366)
- Yun Zeng
- Ke Li
- Yonghua Zhan
- Dehong Chen
- Dan Chen
- Kuoye Tian
Institutions
- Xidian University (CN)
- Xinjiang Medical University (CN)
- Xi'an Medical University (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1186/s12951-026-04436-9
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China