Saikosaponin D Is Associated with Anti-Tumor Effects and Markers of Autophagy and Endoplasmic Reticulum Stress in Human Endometrial Cancer Ishikawa Cells
SSD exerts anti-tumor effects on human EC Ishikawa cells in vitro and in vivo through mechanisms involving DNA damage, G2/M arrest, autophagy, ER stress, and AMPK-mediated inhibition of migration and invasion. These findings suggest that SSD may represent a potential therapeutic agent for EC.
Authors
- Zhao‐Jun Wei (ORCID: https://orcid.org/0000-0003-1729-209X)
- Yi‐Long Ma (ORCID: https://orcid.org/0000-0001-5912-3943)
- Tong-Tong Tang
- Kiran Thakur
- Fei Hu
- Xiao-Mei Ma
- Xiu-Xiu Zhang
Institutions
- Hefei University of Technology (CN)
- Ningxia University (CN)
- North Minzu University (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3390/nu18081221
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Department of Ningxia