Culture Dimensionality Regulates Protein Expression and Bioactivity in THP-1-Derived Macrophages
: These findings demonstrate that culture dimensionality and ECM composition are key regulators of macrophage phenotype and function. Collagen-based 3D systems better reproduce physiologically relevant macrophage behaviors than conventional 2D platforms, highlighting the value of structurally biomimetic models for immunological studies and therapeutic screening.
Authors
- Bill Cheng (ORCID: https://orcid.org/0000-0002-0692-4349)
- Gizem Naz Canko (ORCID: https://orcid.org/0009-0001-2200-8447)
- Shang-Wun Jhang
- Liang-Fang Lin
Institutions
- National Chung Hsing University (TW)
- Changhua Christian Hospital (TW)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3390/biomedicines14040882
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research