Cutaneous <scp> <i>Candida tropicalis</i> </scp> in a Pediatric Acute Lymphoblastic Leukemia Patient: Purpura Without Vascular Invasion

We report a 13-year-old female with B-cell acute lymphoblastic leukemia and neutropenia who developed a purpuric eruption 1 week after resolution of Candida tropicalis fungemia. Repeat blood cultures were negative, yet skin biopsy and tissue culture showed numerous dermal C. tropicalis without vascular invasion. Purpura in neutropenic patients often signals angioinvasive infection, yet studies show Candida-associated purpura may result from vascular injury rather than true vessel invasion. Recognizing this pattern bears clinical significance as non angioinvasive Candida carries a better prognosis and may prevent unnecessary antifungal escalation or surgical intervention.

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Publication Details

Journal
Pediatric Dermatology
Published
2026-04-13
DOI
https://doi.org/10.1111/pde.70210
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
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article

Cutaneous Candida tropicalis in a Pediatric Acute Lymphoblastic Leukemia Patient: Purpura Without Vascular Invasion

Bijal Amin, Hatice B. Zengin, Benedict Wu, B. Nolasco et al.
Pediatric Dermatology
Antifungal resistance and susceptibility
article

Cutaneous Candida tropicalis in a Pediatric Acute Lymphoblastic Leukemia Patient: Purpura Without Vascular Invasion

Bijal Amin, Hatice B. Zengin, Benedict Wu, B. Nolasco, Merav Koschitzky
article en

Abstract

We report a 13-year-old female with B-cell acute lymphoblastic leukemia and neutropenia who developed a purpuric eruption 1 week after resolution of Candida tropicalis fungemia. Repeat blood cultures were negative, yet skin biopsy and tissue culture showed numerous dermal C. tropicalis without vascular invasion. Purpura in neutropenic patients often signals angioinvasive infection, yet studies show Candida-associated purpura may result from vascular injury rather than true vessel invasion. Recognizing this pattern bears clinical significance as non angioinvasive Candida carries a better prognosis and may prevent unnecessary antifungal escalation or surgical intervention.

Pediatric Dermatology
Albert Einstein College of Medicine (US), Montefiore Medical Center (US)
Good health and well-being
Openalex Percentile: Top 16%
Antifungal resistance and susceptibility
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Cutaneous <scp> <i>Candida tropicalis</i> </scp> in a Pediatric Acute Lymphoblastic Leukemia Patient: Purpura Without Vascular Invasion — Bijal Amin, Hatice B. Zengin, et al. · Pediatric Dermatology (2026) | TGRS Research Map | TGRS