Ts-Hsp70 confers dual-stage protective immunity against Trichinella spiralis infection by sustaining M1 macrophage polarization in mice
Background: infection. Objective: infection by reprogramming macrophage polarization to provide multi-stage protection. Methods: -Hsp70 on macrophage phenotype, phagocytic capacity, and T-cell activation. Results: T-cell proliferation. Conclusion: -Hsp70-induced immune protection and reinforce its potential as an effective vaccine antigen against trichinellosis.
Authors
- Qing Sun (ORCID: https://orcid.org/0000-0002-3897-2839)
- Yuan Gu (ORCID: https://orcid.org/0000-0001-5480-5937)
- Shan Liu (ORCID: https://orcid.org/0000-0002-2192-0119)
- Xinping Zhu
- Yi Cheng (ORCID: https://orcid.org/0000-0003-3091-8974)
Institutions
- Capital Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3389/fimmu.2026.1799793
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00