Sorting Nexin 10 Mediates Endosomal Acidification and Autophagy to Promote Influenza A Virus Infection
in mice lungs prolonged survival following IAV challenge. Mechanistically, SNX10 facilitated the production of acidic endosomal vesicles and promoted the accumulation of pro-viral autophagic structures, a process supported by the specific interaction between SNX10 and the viral NP and M2 protein of IAV. Blocking SNX10-mediated acidic endosomal vesicles and autophagosome formation demonstrated antiviral effects. Moreover, IAV infection increased SNX10 protein levels by suppressing its ubiquitination, suggesting that SNX10 could serve as a potential host-derived antiviral drug target.
Authors
- Haobin Li
- Lizhu Chen (ORCID: https://orcid.org/0000-0002-6518-3149)
- Huiyi Guo (ORCID: https://orcid.org/0000-0002-8778-5597)
- Jinlong Liang
- Yingyuan Zhong
- Xucheng He (ORCID: https://orcid.org/0000-0001-7254-6561)
Institutions
- Jinan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Viruses
- Published
- 2026-04-12
- DOI
- https://doi.org/10.3390/v18040460
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province