miRNA-Processing Gene Variants and Neuroblastoma Susceptibility: A Pilot Case-Control Study

BACKGROUND: are associated with NB susceptibility in a Greek pediatric population. MATERIALS AND METHODS: genes were genotyped using TaqMan assays. Logistic regression analyses were adjusted for age and sex, with multiple testing corrections applied via Bonferroni and false discovery rate (FDR) methods. Due to the limited number of NB cases, analyses within this group were considered exploratory. RESULTS: rs10035440. Exploratory within-case analyses provided limited descriptive insights and require validation in larger cohorts. CONCLUSIONS: This pilot study suggests that genetic variations in the miRNA-processing pathway may affect NB susceptibility. Further research involving larger, ethnically diverse cohorts, along with expanded genotype-expression analyses and functional validation, is essential before clinical or prognostic applications can be established.