Tandem amplification of the <i>umpA</i> allele contributes to ceftazidime-avibactam heteroresistance in clinical carbapenem-resistant <i>Klebsiella pneumoniae</i> isolates
strains. These findings suggest that ceftazidime-avibactam heteroresistance is a major clinical concern in eradicating bacterial infections. Furthermore, lipoprotein biosynthetic pathways are considered a promising target for overcoming ceftazidime-avibactam (CZA) resistance.
Authors
- Yuqiao Han
- Jing Yu (ORCID: https://orcid.org/0000-0003-2836-6373)
- Mengyao Wang (ORCID: https://orcid.org/0000-0001-7190-331X)
- Tao Song (ORCID: https://orcid.org/0000-0001-6897-1362)
- Yuyuan Li (ORCID: https://orcid.org/0000-0002-4570-7478)
- Yiling Lin
- Yu Zhang
- Ying Li (ORCID: https://orcid.org/0000-0002-3671-5572)
- Feng Li
- Jia Hu
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1128/spectrum.01722-25
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dalian High-Level Talent Innovation Program
- Department of Education of Liaoning Province
- Dalian Medical University