Neutralization Kinetics and Transport Define the Dermal Decontamination Window for Warfare and Industrial Toxicants
(>8), where rapid bulk neutralization renders surface-based interventions progressively less effective. The framework identifies a critical decontamination window during which the applied decontaminant neutralizes the agent faster than it can enter the bloodstream, thereby minimizing systemic exposure. Implemented as open-source Python software, this tool can help emergency responders and regulatory agencies predict decontamination windows for chemical warfare agents and industrial toxicants.
Authors
- Laurent Simon (ORCID: https://orcid.org/0000-0001-6205-4467)
- Ishita Kulkarni
Institutions
- New Jersey Institute of Technology (US)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Chemical Research in Toxicology
- Published
- 2026-04-12
- DOI
- https://doi.org/10.1021/acs.chemrestox.5c00540
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Army Research Office