Refining Glial Fibrillary Acidic Protein Diagnostics for Prehospital Stroke Triage
When stroke is suspected in the prehospital setting, the ability to rule out intracranial hemorrhage (ICrH) in all ambulances would guide triage decisions, steer early management of hemodynamics, and help prepare the receiving hospital. In this prospective observational study, we investigated the diagnostic performance of plasma glial fibrillary acidic protein (GFAP) for ultra-early rule-out of ICrH in acute cerebral ischemia (ACI) and stroke mimic (SM) patients in a large, unselected stroke-code patient cohort.
Authors
- Juhani Ritvonen
- Daniel Strbian (ORCID: https://orcid.org/0000-0001-9095-2344)
- Olli S. Mattila
- Mikko Pystynen
- Sami Curtze (ORCID: https://orcid.org/0000-0003-1545-8500)
- Tiina Nukarinen
- Saana Pihlasviita
- Perttu J. Lindsberg (ORCID: https://orcid.org/0000-0001-7690-811X)
- Turgut Tatlisumak (ORCID: https://orcid.org/0000-0002-2430-8988)
- Markku Kuisma
- Heini Harve-Rytsälä
- Gerli Sibolt
Institutions
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- University of Gothenburg (SE)
Publication Details
- Journal
- Neurology Open Access
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1212/wn9.0000000000000088
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00