Oncology: What You May Have Missed in 2025

Oncology care increasingly necessitates collaboration with physicians in other specialties. This article highlights 10 studies published in 2025 that we believe are important for nononcologists who participate in the care of patients with cancer. The articles selected provide updates on advancements that influence the full spectrum of oncology care. Several studies present therapeutic developments for lung, colorectal, and breast cancer. A major theme of the 2025 literature is evidence-based de-escalation, including reducing mammographic surveillance in older breast cancer survivors and omitting autologous stem cell transplant in patients with multiple myeloma who achieve measurable residual disease negativity. Another study addresses reduced-dose apixaban for extended cancer-associated thrombosis management and the validation of elinzanetant for nonhormonal management of vasomotor symptoms. These studies collectively move the field toward highly personalized, biomarker-driven interventions that require integrated care models to optimize patient outcomes.