Discovery of a Highly Potent and Selective mTOR Inhibitor that Strongly Suppresses Glioblastoma Multiforme Cell Growth

Authors

Margaret C. Frame (ORCID: https://orcid.org/0000-0001-5882-1942)
Jonathon Mok (ORCID: https://orcid.org/0000-0002-3470-5573)
John C. Dawson (ORCID: https://orcid.org/0000-0001-5713-1026)
Álvaro Lorente‐Macías (ORCID: https://orcid.org/0000-0001-9510-714X)
Neil O. Carragher (ORCID: https://orcid.org/0000-0001-5541-9747)
Asier Unciti-Broceta
Ana Juan-Albuquerque

Institutions

Edinburgh Cancer Research (GB)
University of Edinburgh (GB)

Publication Details

Journal: Journal of Medicinal Chemistry
Published: 2026-04-13
DOI: https://doi.org/10.1021/acs.jmedchem.6c00541
Primary Topic: PI3K/AKT/mTOR signaling in cancer
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Scottish Government
Cancer Research UK
Brain Tumour Charity
Medical Research Council
Institute of Genetics

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article

Discovery of a Highly Potent and Selective mTOR Inhibitor that Strongly Suppresses Glioblastoma Multiforme Cell Growth

Margaret C. Frame, Jonathon Mok, John C. Dawson, Álvaro Lorente‐Macías et al.

Apr 13, 2026

Journal of Medicinal Chemistry

PI3K/AKT/mTOR signaling in cancer

article

Discovery of a Highly Potent and Selective mTOR Inhibitor that Strongly Suppresses Glioblastoma Multiforme Cell Growth

Margaret C. Frame, Jonathon Mok, John C. Dawson, Álvaro Lorente‐Macías, Neil O. Carragher, Asier Unciti-Broceta, Ana Juan-Albuquerque

April 13, 2026article en

Abstract

No abstract available for this paper.

Journal of Medicinal ChemistryVol. 69(8)

Edinburgh Cancer Research (GB), University of Edinburgh (GB)

Scottish Government, Cancer Research UK, Brain Tumour Charity, Medical Research Council, Institute of Genetics

Good health and well-being

Openalex Percentile: Top 20%

PI3K/AKT/mTOR signaling in cancer

DOI Open Access PDF OpenAlex

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