Front Cover: Stability of Information‐Carrying DNA Origami Nanostructures During Repeated Freeze–Thaw Cycles (Chem. Methods 4/2026)

The Front Cover illustrates the thawing of streptavidin-decorated DNA origami nanostructures. Digital information encoded in biotin patterns on DNA origami substrates can be preserved over at least forty freeze-thaw cycles and efficiently read out by streptavidin-biotin binding. Adding glycerol at millimolar concentrations helps to protect the DNA origami shapes from freeze–thaw damage and data loss. Readout efficiency can be further improved by exposing the DNA origami nanostructures to streptavidin only after freeze–thaw cycling. More information can be found in the Research Article by A. Keller and co-workers (DOI: 10.1002/cmtd.202500161).