Epigenetic regulation in cancer chemoresistance and combined therapeutic strategies
. Combining epigenetic drugs with conventional chemotherapy enables multi-level intervention in resistance mechanisms, significantly improving therapeutic outcomes and offering new avenues for personalized cancer treatment. Future studies should focus on developing precise biomarkers, optimizing combination strategies, and conducting clinical validation to advance the application of epigenetic interventions in chemoresistant cancers.
Authors
- Xiulin Jiang (ORCID: https://orcid.org/0000-0001-7986-0465)
- Jia‐Yi Wang (ORCID: https://orcid.org/0000-0002-9106-3351)
- Yuqiang Shi
- Lili Jiang
- Yixiao Yuan
- Dahang Zhang
Institutions
- Kunming Medical University (CN)
- Aerospace Center Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3389/fcell.2026.1814084
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00