A Sequence-Specific Theory for Charge-Regulating IDPs
, we find strong effects of the sequence on ionization, with well-mixed sequences exhibiting a broad pH range where the polypeptide is net neutral, while blockier sequences exhibit a steeper ionization response. Moreover, we also observe pronounced sequence effects on the swelling behavior of the chains.
Authors
- Christian Holm (ORCID: https://orcid.org/0000-0003-2739-310X)
- Zhen‐Gang Wang (ORCID: https://orcid.org/0000-0002-3361-6114)
- David Beyer (ORCID: https://orcid.org/0000-0001-6066-8043)
Institutions
- University of Stuttgart (DE)
- California Institute of Technology (US)
- Division of Chemistry (US)
- Computational Physics (United States) (US)
Publication Details
- Journal
- The Journal of Physical Chemistry B
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1021/acs.jpcb.6c00655
- Primary Topic
- Polymer Surface Interaction Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Innovation and Technology Commission
- German-American Fulbright Program