Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase
of ~ 1.3 µM. Sequence analysis and synthetic probes identified loop 3 as the inhibitory motif. Psysol 3 is a new probe for POP pharmacology and future structure-activity studies.
Authors
- Carina Ebermann
- Roland Hellinger (ORCID: https://orcid.org/0000-0002-8955-8793)
- Christian W. Gruber (ORCID: https://orcid.org/0000-0001-6060-7048)
- Markus Muttenthaler (ORCID: https://orcid.org/0000-0003-1996-4646)
- Kirtikumar B. Jadhav (ORCID: https://orcid.org/0000-0003-3755-5926)
- Jonathan Dieringer
- Paula Schwarz
Institutions
- University of Vienna (AT)
- The University of Queensland (AU)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Natural Products and Bioprospecting
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1007/s13659-026-00598-z
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Austrian Science Fund