Microbial Genomic Consortia in Prostate Cancer: Mechanistic Signaling, the Gut–Prostate Axis, and Translational Perspectives
Microbial genomic consortia in the prostate and gut may shape inflammatory, metabolic, and immune networks that influence PCa initiation and progression. However, most available data remain correlative and are limited by low-biomass sampling, contamination risk, and heterogeneous study designs. Future research should prioritize rigorous contamination control, longitudinal and prostate-specific mechanistic studies, and integrated multi-omic approaches to clarify causality and identify actionable microbial targets for prevention, diagnosis, and therapy.
Authors
- Héctor Martínez Ruiz (ORCID: https://orcid.org/0000-0003-2508-4194)
- Margarito Martínez Cruz (ORCID: https://orcid.org/0000-0002-0379-4630)
- Edgar Zenteno (ORCID: https://orcid.org/0000-0001-5603-4072)
- María Teresa Hernández‐Huerta (ORCID: https://orcid.org/0000-0003-2182-2540)
- Juan de Dios Ruiz‐Rosado (ORCID: https://orcid.org/0000-0002-6429-9086)
- Miriam Villegas (ORCID: https://orcid.org/0000-0002-4871-8658)
- Eduardo Pérez‐Campos Mayoral (ORCID: https://orcid.org/0000-0002-6032-7609)
- Lucía Martínez-Martínez (ORCID: https://orcid.org/0000-0002-0581-8624)
- María del Socorro Pina-Canseco
- Carlos Romero-Díaz
- Eduardo Lorenzo Perez-Campos
- Carlos Mauricio Lastre-Domínguez
- L Pérez-Campos Mayoral
- Hector Alejandro Cabrera-Fuentes
- Gabriel Mayoral-Andrade
- Andrea Paola Cruz-Pérez (ORCID: https://orcid.org/0009-0000-7185-2145)
- Tania Sinaí Santiago-Ramírez
- Diana Palmero-Alcántara (ORCID: https://orcid.org/0009-0005-3803-2424)
- Abelardo Augusto Ramírez-Davila (ORCID: https://orcid.org/0009-0002-9949-9528)
- Bernardo Rodrigo Santiago-Luna
- Javier Vázquez-Pérez (ORCID: https://orcid.org/0009-0006-5103-0164)
- Primitivo Ismael Olivera González
- Erico Briones-Guerash
- Efrén Emmanuel Jarquín-González (ORCID: https://orcid.org/0009-0009-4203-5555)
Institutions
- Nationwide Children's Hospital (US)
- Instituto Tecnológico de Oaxaca (MX)
- Universidad del Mar (MX)
- Secretaria de Salud (HN)
- Instituto Tecnológico de Tijuana (MX)
- Imam Abdulrahman Bin Faisal University (SA)
- Universidad Nacional Autónoma de México (MX)
- Benito Juárez Autonomous University of Oaxaca (MX)
Publication Details
- Journal
- Cancers
- Published
- 2026-04-12
- DOI
- https://doi.org/10.3390/cancers18081219
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00