Thioester-Containing Ionizable Lipids with Enhanced Endosomal Escape and Biodegradability for mRNA and tRNA Delivery
: The rapid biodegradability of these thioester-activated ionizable lipids (TAILs) suggests a reduced risk of accumulation, with the potential to enable safe repeated dosing or high-dosage RNA therapies, positioning TAILs as a versatile and safe platform for next-generation RNA therapeutics.
Authors
- Carlos Matute (ORCID: https://orcid.org/0000-0001-8672-711X)
- Álvaro Peña (ORCID: https://orcid.org/0000-0002-3517-4102)
- Ana Gallego-Lleyda
- Teresa Alejo (ORCID: https://orcid.org/0000-0002-9324-0446)
- Javier Giménez-Warren (ORCID: https://orcid.org/0000-0002-1747-6393)
- Esther Broset (ORCID: https://orcid.org/0000-0003-4155-749X)
- Laura García-Latorre
- Enrique García Lucía
- Eduardo Romanos (ORCID: https://orcid.org/0000-0002-9918-3374)
- Vı́ctor Navarro (ORCID: https://orcid.org/0000-0001-6925-4605)
- Juan Martínez-Oliván
- Alba García (ORCID: https://orcid.org/0009-0000-9760-5433)
Institutions
- Universidad de Zaragoza (ES)
- Instituto de Investigación Sanitaria Aragón (ES)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3390/pharmaceutics18040472
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia e Innovación
- Gobierno de Aragón
- Agencia Estatal de Investigación