The Role of Cav1.1‐Ca <sup>2+</sup> ‐ <scp>IGF</scp> ‐1 in <scp>EMS</scp> Preventing Denervated Intrinsic Muscle Atrophy Induced by Brachial Plexus Injury
activates the translation rather than transcription of IGF-1. Crucially, long-term and regular EMS sustains elevated IGF-1 levels, which subsequently modulates protein metabolism in myocytes, thereby mitigating denervated muscle atrophy.
Authors
- Hongze Yan
- Xinyu Zhao (ORCID: https://orcid.org/0000-0002-5128-4424)
- Yuzhou Liu (ORCID: https://orcid.org/0000-0002-7798-8323)
- Jing Rui (ORCID: https://orcid.org/0000-0003-3587-5985)
- Kaiming Gao
- Guokang Mo
- Jie Lao
- Chengpeng Liao
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Huashan Hospital (CN)
- Shanghai Micro Electronics Equipment (China) (CN)
Publication Details
- Journal
- The FASEB Journal
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1096/fj.202503732rr
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Key Laboratory of Peripheral Nerve and Microsurgery
- Sanming Project of Medicine in Shenzhen