Targeting CAFs-derived PCSK6 inhibits redistribution of PD-L1 and restores response of CD8+T cells against colorectal cancer
T cells, alleviated growth of CRC and conferred survival advantage in tumor-bearing mice. Moreover, the membrane level of PD-L1 was mediated by the membrane transport complex Rab8/EHBP1L1. Our finding suggested PCSK6/ACVR1B-p300-Rab8/EHBP1L1-PD-L1 signaling axis is significantly activated by CAFs-derived PCSK6, which may offer mechanism interpretation for CAFs mediated CRC immune escape and suggest potential mechanism-based therapeutic strategies for ACVR1B antagonist.
Authors
- Hongting Diao (ORCID: https://orcid.org/0000-0002-0795-8647)
- Yuxiang Fei
- Qianming Du
- Xu ZHANG (ORCID: https://orcid.org/0000-0001-7937-3827)
- Wenlian Tang
- Sheng Hu
- Tao Li
- Ya Yang
- Deju Wang
Institutions
- Xinjiang Medical University (CN)
- China Pharmaceutical University (CN)
- Chengdu University (CN)
- Second Affiliated Hospital of Chengdu University of Traditional Chinese (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cell Death and Differentiation
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1038/s41418-026-01736-3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00