Synthesis of Polyhydroxylated Pyrrolidinyl Analogs of Sugar Nucleotides. Experimental and Computational Studies on Their Interactions With GalNAC‐T's
values have been used to validate the binding model at the active site. These studies provide important information of the role of the pyrophosphate and pyrrolidinyl moieties on the observed affinity.
Authors
- Ignacio Delso (ORCID: https://orcid.org/0000-0001-8355-2289)
- Veronica Juste
- Manuel Pedrón (ORCID: https://orcid.org/0000-0003-4249-6748)
- Sonsoles Martín‐Santamaría (ORCID: https://orcid.org/0000-0002-7679-0155)
- Ana I. Jiménez (ORCID: https://orcid.org/0000-0001-8057-4861)
- Sara Orta
- Sandra C. Pereira
- Tomás Tejero (ORCID: https://orcid.org/0000-0003-3433-6701)
- Pedro Merino
- Alejandro Montesa
- Ramón Hurtado‐Guerrero
Institutions
- Universidad de Zaragoza (ES)
- Instituto de Síntesis Química y Catálisis Homogénea (ES)
- Centro de Investigaciones Biológicas Margarita Salas (ES)
Publication Details
- Journal
- ChemBioChem
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1002/cbic.202500955
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia e Innovación
- Universidad de Zaragoza
- Gobierno de Aragón