Pulsed Field Ablation for the Interventional Treatment of Atrial Fibrillation. A Scientific Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin
Pulsed field ablation has emerged as a novel non-thermal treatment modality with a distinct safety profile for the interventional treatment of atrial fibrillation. By inducing irreversible electroporation, pulsed field ablation achieves myocardial ablation while preserving surrounding structures such as nerves, vasculature, and the esophagus. This European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC) scientific statement, endorsed by major international societies, reviews the biophysics, technology, clinical evidence, workflow, safety, and training aspects of pulsed field ablation. Randomized trials demonstrate comparable efficacy to radiofrequency and cryoballoon ablation, with advantages in safety and efficiency. The statement provides practical advice for clinical implementation, operator training, and identifies key gaps in evidence and priorities for future research and innovation.
Authors
- Helmut Pürerfellner (ORCID: https://orcid.org/0000-0002-8965-8495)
- Stylianos E. Tzeis (ORCID: https://orcid.org/0000-0002-2007-1928)
- Bradley Wilsmore (ORCID: https://orcid.org/0000-0002-8254-2705)
- Heiko Lehrmann (ORCID: https://orcid.org/0000-0003-2377-1417)
- Jonathan Paul Piccini (ORCID: https://orcid.org/0000-0003-0772-2404)
- JKR Chun
- Kars Neven (ORCID: https://orcid.org/0000-0002-2075-8113)
- Ante Anić (ORCID: https://orcid.org/0000-0002-6864-3999)
- Raphaël Rosso (ORCID: https://orcid.org/0000-0003-0303-1497)
- Hiroshi Tada (ORCID: https://orcid.org/0000-0001-8578-2328)
- Atul Verma (ORCID: https://orcid.org/0000-0002-1020-9727)
- Martin Huth Ruwald (ORCID: https://orcid.org/0000-0002-1541-309X)
- Michael Kühne (ORCID: https://orcid.org/0000-0002-2937-3711)
- Pierre Jaı̈s (ORCID: https://orcid.org/0000-0002-4700-7811)
- Damijan Miklavčič (ORCID: https://orcid.org/0000-0003-3506-9449)
- Patrick Badertscher (ORCID: https://orcid.org/0000-0001-9751-0557)
- Josef Kautzner (ORCID: https://orcid.org/0000-0002-1632-6182)
- Andrea Sarkozy (ORCID: https://orcid.org/0000-0001-6327-0487)
- Antonio Dello Russo (ORCID: https://orcid.org/0000-0001-7737-421X)
- Jason G. Andrade (ORCID: https://orcid.org/0000-0002-8493-5123)
- Arian Sultan (ORCID: https://orcid.org/0000-0003-1807-4860)
- Tobias Reichlin (ORCID: https://orcid.org/0000-0002-7197-8415)
- Armando Pérez-Silva (ORCID: https://orcid.org/0000-0003-1825-8766)
- Claire A Martin
- Jose Luis Merino
- Andrea Natale (ORCID: https://orcid.org/0000-0001-6601-944X)
- Daniel Scherr (ORCID: https://orcid.org/0000-0001-5868-5493)
Institutions
- University of Fukui (JP)
- Marche Polytechnic University (IT)
- University of Copenhagen (DK)
- Heart Rhythm Society (US)
- Université de Bordeaux (FR)
- University of Ljubljana (SI)
- Medical University of Graz (AT)
- Royal Papworth Hospital (GB)
- Tel Aviv Sourasky Medical Center (IL)
- University Hospital of Bern (CH)
- University Medical Center Freiburg (DE)
- McGill University Health Centre (CA)
- University Hospital of Basel (CH)
- Vancouver General Hospital (CA)
- Clinical Research Institute (US)
- Cardiovascular Center Bethanien (DE)
- Tweed Shire Council (AU)
- Heart Foundation (US)
- Hospital La Paz Institute for Health Research (ES)
- Hôpital Cardiologique du Haut-Lévêque (FR)
- Hospital Regional de Concepción (CL)
- Asklepios Klinik St. Georg (DE)
- Universitair Ziekenhuis Brussel (BE)
- Institute of Clinical and Experimental Medicine (CZ)
- Krankenhaus der Elisabethinen (AT)
- Mitera Hospital (GR)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
- Klinički Bolnički Centar Split (HR)
- Texas Cardiac Arrhythmia (US)
- Alfried Krupp Hospital (DE)
- McGill University (CA)
- Universidad Autónoma de Madrid (ES)
- University of Split (HR)
Publication Details
- Journal
- EP Europace
- Published
- 2026-04-10
- DOI
- https://doi.org/10.1093/europace/euag080
- Citations
- 1
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 19.82