The ratio of LDL-C to HDL-C can effectively predict the prognosis of IgA nephropathy

Background: Abnormal lipid metabolism affects IgA nephropathy (IgAN) prognosis, but the prognostic value of LDL-C/HDL-C ratio in IgAN remains unclear. Methods: A bicenter retrospective cohort study enrolled 1,405 IgAN patients with a median follow-up of 50.1 months. Patients were divided into four quartiles based on LDL-C/HDL-C ratio (Q1: lowest quartile, Q4: highest quartile). Kaplan-Meier, Cox regression, and restricted cubic spline (RCS) analyses were used to explore the association between LDL-C/HDL-C ratio and end-stage renal disease (ESRD) risk. Results: = 0.624). Conclusion: Elevated LDL-C/HDL-C ratio constitutes an independent risk factor for end-stage renal disease (ESRD) in patients with IgA nephropathy (IgAN), demonstrating a linear dose-response relationship and serving as a reliable prognostic biomarker independent of IgA deposition.