Mechanistic study of inspiratory training in childhood Asthma: Rationale and methods of a pediatric clinical trial
= 38) 6-17-year-olds with asthma and (2) measure small airway disease and inspiratory muscle function in response to 8 weeks of inspiratory training. We will also assess physical fitness, activity levels, and exertional dyspnea. This study will lay the foundation for dose selection and optimal target population of a larger trial. IT could represent a novel therapy to help children with asthma and obesity improve quality of life through reduced exertional symptoms and enhanced activity levels.
Authors
- Melissa C. Orenduff (ORCID: https://orcid.org/0000-0001-7652-073X)
- Harrison N. Jones (ORCID: https://orcid.org/0000-0002-4171-980X)
- Jason E. Lang (ORCID: https://orcid.org/0000-0001-9115-5312)
- Dharini M. Bhammar (ORCID: https://orcid.org/0000-0003-3358-2169)
- Tarig Ali‐Dinar
- Benjamin A. Goldstein
- Angel Davalos
Institutions
- Duke University (US)
- The Ohio State University Wexner Medical Center (US)
- Clinical Research Institute (US)
- The Ohio State University (US)
Publication Details
- Journal
- Contemporary Clinical Trials Communications
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1016/j.conctc.2026.101638
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute
- National Cancer Institute