Multiscale stochastic modeling for calcium dynamics in cardiac electrophysiology: assessing whole-cell model reliability under phosphorylation and LCC downregulation
LCCs (with mild sensitivity to the RyR:LCC scaling). However, under high phosphorylation or LCC upregulation, stochasticity persists and convergence to deterministic-like behavior is absent or markedly delayed even for total LCC numbers as large as 20,000. In these conditions, whole-cell deterministic models become doubtful, since their behavior can be qualitatively different from that arising from any plausibly mediated coordination of subcellular calcium release units.
Authors
- Rodrigo Weber dos Santos (ORCID: https://orcid.org/0000-0002-0633-1391)
- Sergio Alonso (ORCID: https://orcid.org/0000-0002-3989-8757)
- Enrique Álvarez-Lacalle (ORCID: https://orcid.org/0000-0001-6824-6857)
- Gustavo Montes Novaes (ORCID: https://orcid.org/0000-0002-1484-5093)
Institutions
- Universidade Federal de Juiz de Fora (BR)
- Federal Center for Technological Education of Minas Gerais (BR)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- Frontiers in Network Physiology
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3389/fnetp.2026.1727426
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Financiadora de Estudos e Projetos
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Universitat Politècnica de Catalunya
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- European Regional Development Fund
- Agencia Estatal de Investigación