Respiratory Models Reveal DNA Damage Response Modulation by Merkel Cell Polyomavirus
, were examined. Our findings showed MCPyV replication in all cellular systems, as proven by the detection of viral DNA and transcripts. Viral infection induced an overexpression of DDR genes, suggesting a role of the virus in manipulating DDR to favor its replication or contribute to tumor progression. These preliminary results provide in vitro models for studying the interplay between MCPyV and DDR within malignant and non-malignant contexts across the respiratory tract, laying the basis for future research exploring the clinical relevance of DDR activation in virus-driven malignancies.
Authors
- Marta De Angelis (ORCID: https://orcid.org/0000-0002-1916-6508)
- Lucia Nencioni (ORCID: https://orcid.org/0000-0003-4427-4823)
- Cecilia Ambrosi (ORCID: https://orcid.org/0000-0003-2163-1613)
- Valeria Pietropaolo (ORCID: https://orcid.org/0000-0001-5723-8886)
- Ugo Lionel Moens (ORCID: https://orcid.org/0000-0002-1931-5462)
- Daniela Scribano (ORCID: https://orcid.org/0000-0002-2901-265X)
- Sara Passerini (ORCID: https://orcid.org/0000-0002-0678-5537)
Institutions
- Vita-Salute San Raffaele University (IT)
- IRCCS Ospedale San Raffaele (IT)
- Istituto Pasteur (IT)
- UiT The Arctic University of Norway (NO)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-12
- DOI
- https://doi.org/10.3390/ijms27083449
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute