Isavuconazole in Pediatric Invasive Fungal Infections: Outcomes and Therapeutic Drug Monitoring in a Chinese Multicenter Case Series

Background: Real-world evidence regarding the efficacy of isavuconazole (ISA) for pediatric invasive fungal infections (IFIs) remains scarce, particularly in Asia. Methods: ) was performed using LC-MS/MS targeting 2-4 mg/L. The clinical pharmacists provided weekly antifungal stewardship interventions. Results: /MIC (183.5) strongly predicts the success of mold infections. No QTc prolongation or severe hepatotoxicity was observed. Conclusion: This first Chinese multicenter pediatric series demonstrated the excellent efficacy and tolerability of ISA when combined with routine TDM and clinical pharmacist stewardship. It should be noted that our study has a small sample size, requiring further validation.