Targeting m <sup>6</sup> A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma
T cells in ICCs. In addition, targeting YTHDF1 alongside blockade of its downstream chemokine pathway enhanced the efficacy of anti-PD-L1 treatment in preclinical ICC mouse models, serving a promising strategy for improving immunotherapy efficacy in ICC.
Authors
- Fei Fang (ORCID: https://orcid.org/0009-0007-4011-9742)
- Zimin Song (ORCID: https://orcid.org/0000-0002-0302-3502)
- Lu Luo (ORCID: https://orcid.org/0000-0002-9151-6410)
- X. Li
- Ziqin Liu
- Kai Lei
- Ming Kuang
- Dong Zhang
- Jun Yu (ORCID: https://orcid.org/0000-0001-5008-2153)
- Lixia Xu
- Lina Wang
- Shiyan Wang
- Shunli Shen
- Weikang Chen
Institutions
- Sun Yat-sen University (CN)
- Chinese University of Hong Kong (HK)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1002/advs.202520403
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation