Primary lateral sclerosis in Brazil: phenotypic heterogeneity, non-motor features, and prognostic markers in a 17-year multicentre cohort
This first Latin American PLS cohort demonstrates clinical characteristics comparable to those reported in international studies. Extrapyramidal signs emerged as a high-risk marker. Hemiparetic presentations appear transitional, and non-motor manifestations support PLS as a multisystem disorder.
Authors
- Christian Marques Couto (ORCID: https://orcid.org/0000-0001-7479-4489)
- Eduardo Boiteux Uchôa Cavalcanti (ORCID: https://orcid.org/0000-0001-7763-7745)
- Osvaldo J. M. Nascimento (ORCID: https://orcid.org/0000-0003-3516-485X)
- Ricardo Silva Carvalho (ORCID: https://orcid.org/0000-0001-8045-5600)
- Alessandra de La Roque Ferreira
- Cecilia Vidal Watkins
- Waneska Souza Lima
Institutions
- Universidade Federal Fluminense (BR)
- Instituto Federal Fluminense (BR)
- Sarah Network of Rehabilitation Hospitals (BR)
- Universidade Presidente Antônio Carlos (BR)
Publication Details
- Journal
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1080/21678421.2026.2652325
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00