Gut-targeted strategies at the intersection of radiotherapy and immunotherapy
's study, including challenges in attribution, heterogeneity, and immunosuppression. We also discuss complementary translational approaches, including direct microbiota modulation through targeted antibiotics and other gut-directed strategies, as potential tools to experimentally interrogate the microbiota-RT-immunotherapy axis in patients.
Authors
- Susannah G. Ellsworth (ORCID: https://orcid.org/0000-0001-8546-3642)
- Andrea Facciabene (ORCID: https://orcid.org/0000-0002-9563-297X)
Institutions
- Cancer Research Center (US)
- University of Pittsburgh Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1136/jitc-2025-014211
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute