Underlying MASLD-induced gut microbiome dysbiosis and intestinal inflammation are key to poor outcomes in vibriosis infections in a preclinical model
to investigate the pathophysiological outcomes in both control and diet-induced MASLD mouse cohorts. Our results showed that non-cholera vibriosis in mice with underlying MASLD caused increased liver damage, an inflammatory surge, followed by the onset of fibrotic lesions compared to the chow-diet fed control mice, depicting a worsened outcome. Depletion of the gut bacteriome by antibiotic treatment and following fecal microbiota transplantation in these mouse cohorts showed decreased pathophysiology in the livers, indicating that an altered gut microbiome in MASLD could be a key factor in the increased likelihood of non-cholera vibriosis in patients with MASLD.
Authors
- Anna Mae Diehl (ORCID: https://orcid.org/0000-0003-1859-089X)
- Bryan W. Brooks (ORCID: https://orcid.org/0000-0002-6277-9852)
- Subhajit Roy
- Dipro Bose (ORCID: https://orcid.org/0000-0002-9909-6975)
- Saurabh Chatterjee (ORCID: https://orcid.org/0000-0003-1649-7149)
- Madhura More (ORCID: https://orcid.org/0000-0002-5440-0216)
- Ayushi Trivedi
- Punnag Saha (ORCID: https://orcid.org/0000-0001-6173-9798)
- Wing-Kin Syn
Institutions
- Baylor University (US)
- University of the Basque Country (ES)
- Duke University (US)
- University of California, San Francisco (US)
- University of Occupational and Environmental Health Japan (JP)
- Center for Environmental Health (US)
- University of California San Diego (US)
- UCLouvain Saint-Louis Brussels (BE)
- Saint Louis University (US)
Publication Details
- Journal
- Gut Microbes
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1080/19490976.2026.2652474
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Environmental Health Sciences