Synthesis of Carborane-Containing Flavone and Flavonol Analogues as ER Agonists and COX Inhibitors
of 0.87 ± 0.07 μM for ERα and a selectivity of 12.8-fold toward ERβ. These compounds also showed moderate inhibitory activities toward COX-1 and COX-2.
Authors
- Yirong Zhang (ORCID: https://orcid.org/0000-0002-1026-5569)
- Sinan Wang (ORCID: https://orcid.org/0000-0002-6282-1408)
- Chenyang Ma (ORCID: https://orcid.org/0009-0008-9480-3520)
- Hui Li (ORCID: https://orcid.org/0000-0001-9198-3951)
- Yong Nian (ORCID: https://orcid.org/0009-0000-2571-696X)
- Linlin Wang (ORCID: https://orcid.org/0000-0002-7014-2149)
- Zekun Yang (ORCID: https://orcid.org/0000-0003-4040-8476)
- Yuxin Lin
- Changxian Yuan
- Guanxiang Hao
- Yuan Li
- Nan Sun
Institutions
- Nanjing University of Chinese Medicine (CN)
- ShanghaiTech University (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c01639
- Primary Topic
- Boron Compounds in Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Nanjing University of Chinese Medicine
- ShanghaiTech University
- National Key Research and Development Program of China