Repurposing trifluoromethyl copper (III) complexes for difluoromethylation of saccharides and complex alcohols
, which serves a dual role as a hydroxyl activator and an in situ source of hydrogen chloride. Antifungal activity evaluation reveals that compounds 3c and 3n possess good efficacy, highlighting their potential as promising leads for antifungal development.
Authors
- Wen‐Xin Lv (ORCID: https://orcid.org/0000-0002-9114-4258)
- Yonggui Robin (ORCID: https://orcid.org/0000-0003-0573-257X)
- Shuolu Dai
- Tingting Li
- Chuhong Xie
- Shan Long
Institutions
- Nanyang Technological University (SG)
- Guizhou University (CN)
- Guizhou Minzu University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1038/s41467-026-71706-3
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 12.80
Funders
- National Research Foundation
- National Research Foundation Singapore
- Ministry of Education - Singapore
- Nanyang Technological University
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Guizhou University
- Ministry of Education, India
- Young Scientists Fund
- Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- National Key Research and Development Program of China
- Project 211