Exploring functional transitions of the 2’-dG riboswitch aptamer
ions have a significant stabilizing effect, especially on the tertiary structures and on the regulatory helix P1, creating magnesium-mediated attractive interactions between phosphate groups in some cases. The mechanism proposed by experimentalists for the functional transition requires the breaking of the P1 helix. This process occurs on relatively slow timescales, and therefore necessitates the proposed model which allows direct connection to experimental observations.
Authors
- Erdong Ding
- Karissa Y. Sanbonmatsu (ORCID: https://orcid.org/0000-0002-7965-7392)
- José N. Onuchic (ORCID: https://orcid.org/0000-0002-9448-0388)
- Susmitnarayan Chaudhury (ORCID: https://orcid.org/0000-0002-2334-5226)
Institutions
- Los Alamos National Laboratory (US)
- New Mexico Consortium (US)
- Center for Theoretical Biological Physics (US)
- Rice University (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1073/pnas.2528806123
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Los Alamos National Laboratory Foundation
- National Science Foundation
- National Institutes of Health