Design and Development of Teixobactin Analog-Loaded Magnetic Nanocomposites for Biofilm Destruction and Pathogen Elimination
). The biofilm thickness was reduced from 19.4 ± 2.9 µm to 7.4 ± 1.0 µm, and the biofilm biomass was reduced by 68.5%. This combined strategy integrates enzymatic EPS degradation, magneto-mechanical disruption, and dual antimicrobial action, offering a promising topical therapy for periodontitis and peri-implantitis.
Authors
- C Zhang
- Huaxiang Lei (ORCID: https://orcid.org/0000-0002-7261-7128)
- Xiaofeng Li (ORCID: https://orcid.org/0000-0002-2016-290X)
- Ye Liang
- Ting Zou
Institutions
- Fujian Medical University (CN)
- State Key Laboratory of Synthetic Chemistry (CN)
- Stomatology Hospital (CN)
- Fujian Provincial Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Functional Biomaterials
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3390/jfb17040189
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- University of Hong Kong
- Health and Medical Research Fund