Formal Regioselective C–H Sulfinylation of Alkenes with Sulfinyl Sulfones
Sulfinyl sulfones represent a versatile class of sulfur-transfer reagents. In this work, we developed a novel application for these reagents through the direct incorporation of sulfinyl moieties into alkenes, providing an efficient and facile protocol for the synthesis of alkenyl sulfoxides. This methodology is distinguished by its mild reaction conditions, operational simplicity, and excellent regioselectivity. Mechanistic investigations through control experiments reveal that the reaction proceeds via a radical addition-coupling followed by an E2 elimination sequence.
Authors
- Zikun Wang (ORCID: https://orcid.org/0000-0002-8672-4311)
- Yong Li (ORCID: https://orcid.org/0000-0003-4038-0493)
- Xinwei Li (ORCID: https://orcid.org/0000-0003-0555-2624)
- Ruikang Gao
- Wanting Fu
- Yilin Xing
- Xinyu Song
- Hualong Chen
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Capital University (US)
- Capital Medical University (CN)
- Ministry of Science and Technology (VN)
- Hebei University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1021/acs.orglett.6c01034
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province