Automated Imaging Differentiation for Dementia
Differentiation of Alzheimer disease dementia (ADD) and dementia with Lewy bodies (DLB) remains a challenge. Free-water (FW) imaging has been investigated in neurodegenerative diseases and was found to be associated with neurodegeneration and neuroinflammation. This retrospective cohort study tested whether Automated Imaging Differentiation for Dementia (AIDD), combining diffusion free-water imaging (FWI) and support vector machine, predicts ADD vs DLB with high accuracy.
Authors
- Robin Chen
- Lyles Clark
- David E. Vaillancourt (ORCID: https://orcid.org/0000-0002-5663-6476)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Hamsanandini Radhakrishnan (ORCID: https://orcid.org/0000-0002-4448-986X)
- Jesse C. DeSimone (ORCID: https://orcid.org/0000-0002-3823-8765)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Kejal Kantarci (ORCID: https://orcid.org/0000-0002-8001-2081)
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
- Angelos Barmpoutis (ORCID: https://orcid.org/0000-0003-3271-7965)
- Shannon Chiu (ORCID: https://orcid.org/0000-0001-6143-9867)
- Wei Wang (ORCID: https://orcid.org/0000-0001-6853-7785)
Institutions
- University of Florida (US)
- Mayo Clinic in Arizona (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Neurology Open Access
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1212/wn9.0000000000000093
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00