Genetic insights into unexplained infant jaundice: a study from northern Guangdong, China

Objective: To explore the genetic factors contributing to unexplained infant jaundice and evaluate the significance of gene screening related to jaundice. Methods: Infants jaundice with unknown etiology attending the neonatology and pediatrics departments of Yuebei People's Hospital from January 2022 to July 2024 were selected as the subjects of this study. The exon regions of 161 jaundice-related genes were detected by targeted capture and high-throughput sequencing technology, and the results were statistically analyzed. Results: gene c.800C>T site. Conclusion: genes, which have high-frequency mutation sites within the population. Conducting genetic screening for infants with jaundice of unknown etiology holds significant clinical importance.