Gelatin Sponge-Embedded Adipose-Derived Stromal Cells Enable Allogeneic Application for Revascularization of Ischemic Wounds
T-cell infiltration was detected. Histology confirmed efficacy on ischemic wounds, with increased granulation tissue thickness, red blood cell infiltration, and enhanced vessel density versus controls. Allogeneic ASCs activated by a gelatin scaffold promote wound revascularization without eliciting immune rejection, supporting their development as standardized, off-the-shelf therapies for chronic ischemic wounds.
Authors
- Damien Pastor (ORCID: https://orcid.org/0000-0002-4377-0692)
- Nicolo-Constantino Brembilla
- Manon Locatelli
- Olivier Preynat‐Seauve (ORCID: https://orcid.org/0000-0001-5364-967X)
- Wolf‐Henning Boehncke (ORCID: https://orcid.org/0000-0002-1225-7124)
- Jean Villard
Institutions
- University of Geneva (CH)
- L.A.C. (Switzerland) (CH)
- University Hospital of Geneva (CH)
- Geneva College (US)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3390/ijms27083482
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canton de Genève
- Innosuisse - Schweizerische Agentur für Innovationsförderung