Diagnostic pearls and pitfalls in the radiologic evaluation of hepatic alveolar echinococcosis

Hepatic alveolar echinococcosis is a tumor-mimicking parasitic disease characterized by infiltrative hepatic involvement and substantial radiologic overlap with malignancy. Predominantly solid morphology, pseudo-capsular margins, and deceptive enhancement patterns frequently contribute to misclassification as primary or secondary liver cancer. Intralesional calcifications on non-contrast computed tomography (CT) and the absence of true arterial phase hyperenhancement on CT and magnetic resonance imaging represent important diagnostic clues. Diffusion-weighted imaging may further aid characterization, although overlap with malignant lesions persists. Accurate interpretation requires systematic multimodality imaging assessment integrated with clinical and serologic context. Increased awareness of characteristic imaging features and common pitfalls is essential to reduce diagnostic delay and prevent inappropriate oncologic management.

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Publication Details

Journal
Diagnostic and Interventional Radiology
Published
2026-04-14
DOI
https://doi.org/10.4274/dir.2026.263966
Primary Topic
Parasitic infections in humans and animals
Type
article
Field-Weighted Citation Impact
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article

Diagnostic pearls and pitfalls in the radiologic evaluation of hepatic alveolar echinococcosis

Hayri Oğul, Ayça Seyfettin, Mecit Kantarcı, Ezgi Güler et al.
Diagnostic and Interventional Radiology
Parasitic infections in humans and animals
article

Diagnostic pearls and pitfalls in the radiologic evaluation of hepatic alveolar echinococcosis

Hayri Oğul, Ayça Seyfettin, Mecit Kantarcı, Ezgi Güler, Ece Zengin, Önder Durmaz
article en

Abstract

Hepatic alveolar echinococcosis is a tumor-mimicking parasitic disease characterized by infiltrative hepatic involvement and substantial radiologic overlap with malignancy. Predominantly solid morphology, pseudo-capsular margins, and deceptive enhancement patterns frequently contribute to misclassification as primary or secondary liver cancer. Intralesional calcifications on non-contrast computed tomography (CT) and the absence of true arterial phase hyperenhancement on CT and magnetic resonance imaging represent important diagnostic clues. Diffusion-weighted imaging may further aid characterization, although overlap with malignant lesions persists. Accurate interpretation requires systematic multimodality imaging assessment integrated with clinical and serologic context. Increased awareness of characteristic imaging features and common pitfalls is essential to reduce diagnostic delay and prevent inappropriate oncologic management.

Diagnostic and Interventional Radiology
University of Health Science (KH), Erzincan Binali Yıldırım University (TR), Ege University (TR), Güven Hospital (TR), Sağlık Bilimleri Üniversitesi (TR), Turkish Society of Cardiology (TR), Atatürk University (TR), University of Health Sciences Antigua (AG)
Good health and well-being
Openalex Percentile: Top 24%
Parasitic infections in humans and animals
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Diagnostic pearls and pitfalls in the radiologic evaluation of hepatic alveolar echinococcosis — Hayri Oğul, Ayça Seyfettin, et al. · Diagnostic and Interventional Radiology (2026) | TGRS Research Map | TGRS