Isolation and characterization of two new cytotoxic glycosylsphingolipids from the stem bark of Pithecellobium eriorhachis Harms. (Fabaceae)
= 4.78 ± 0.56 μg/mL). Pithecellobioside B (2) is identified as a potent cytotoxic compound that warrants further investigation for the development of novel antiproliferative drugs targeting LN229 epithelial-like glioblastoma cells. These findings indicate that Pithecellobiosides A and B (1-2) represent new cerebrosides with selective cytotoxicity against glioblastoma cells, highlighting P. eriorachis as a promising source of bioactive glycosphingolipids.
Authors
- Steven Collins Njonté Wouamba (ORCID: https://orcid.org/0000-0002-7398-8203)
- Éric Allémann (ORCID: https://orcid.org/0000-0002-6598-9521)
- Raduis Melong (ORCID: https://orcid.org/0000-0003-0178-5949)
- Jean Paul Dzoyem (ORCID: https://orcid.org/0000-0003-3568-6711)
- Florence Delié (ORCID: https://orcid.org/0000-0002-2637-5949)
- Michel Gelbcke
- Gilbert Deccaux Wabo Fotso Kapche
- Armelle Tsamo Tontsa
- Franck Meyer
Institutions
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- Université Libre de Bruxelles (BE)
- Université de Yaoundé I (CM)
- Université de Bourgogne (FR)
- Université de Dschang (CM)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut Agro Dijon (FR)
Publication Details
- Journal
- Fitoterapia
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1016/j.fitote.2026.107248
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung