Synergistic Activity of Eugenol, Cinnamaldehyde, and Carvacrol in Combination with Different Antibacterial Agents Against Multidrug-Resistant Gram-Negative Clinical Isolates
: Our data demonstrate that this synergistic interaction was not affected by different antimicrobial resistance genes and/or different antimicrobial susceptibility profiles. In conclusion, our results suggest that eugenol, cinnamaldehyde, and carvacrol in combination with colistin represent a potential strategy for the treatment of MDR-GNB pathogens and limit their diffusion.
Authors
- Paolo Gaibani (ORCID: https://orcid.org/0000-0003-3791-8635)
- Maria Chiara Valerii (ORCID: https://orcid.org/0000-0002-4404-0552)
- Rocco Latorre (ORCID: https://orcid.org/0000-0003-2737-8233)
- Caterina Signoretto (ORCID: https://orcid.org/0000-0002-1439-0447)
- Alessia Pardo (ORCID: https://orcid.org/0000-0002-6466-9825)
- Marco Benati (ORCID: https://orcid.org/0000-0002-0140-3640)
- Enzo Spisni (ORCID: https://orcid.org/0000-0002-8525-2981)
- Giuseppe Lippi (ORCID: https://orcid.org/0000-0001-9523-9054)
- Massimo Albanese (ORCID: https://orcid.org/0000-0002-8108-0617)
Institutions
- University of Verona (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- New York University (US)
- University of Bologna (IT)
Publication Details
- Journal
- Antibiotics
- Published
- 2026-04-11
- DOI
- https://doi.org/10.3390/antibiotics15040391
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Verona