Nitrogen Isotope Effects in Urea Metabolism: From Biochemistry to 15N Natural Abundance in Cancer
N-depleted urea, may shape the isotopic composition of cancer cells. By integrating molecular oncology with stable isotope analysis, this review highlights the potential of natural isotope abundance as a functional readout of tumour metabolism and supports further investigation of its translational relevance in cancer phenotyping and monitoring.
Authors
- Guillaume G. B. Tcherkez (ORCID: https://orcid.org/0000-0002-3339-956X)
- Illa Tea
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Australian National University (AU)
- Centre National de la Recherche Scientifique (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut de Recherche en Horticulture et Semences (FR)
- Université d'Angers (FR)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-12
- DOI
- https://doi.org/10.3390/ijms27083462
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centre National de la Recherche Scientifique
- Institut National Du Cancer