Prospective Predictors of Poor Emotional Functioning in Patients with Differentiated Thyroid Carcinoma

BACKGROUND: The health-related quality of life (HRQoL) of patients with differentiated thyroid carcinoma (DTC), especially their mental health, can be compromised by various factors beyond disease prognosis and treatment stage. However, predictors of poor emotional functioning (EF) in DTC patients have not been thoroughly studied. To inform targeted interventions that could improve or preserve HRQoL in patients with DTC, this study aimed to identify predictors of impaired EF, and particularly modifiable factors. METHODS: = 196) were assessed at three timepoints before treatment (t1), 6 weeks after the start of treatment (t2), and 6 months after t2 (t3). Multilevel, multivariable logistic regression models were used to assess the likelihood of impaired EF at t3 according to predefined potential predictors at t1 and t2. RESULTS: = 0.001) per score point, respectively. There was no evidence that worry about important others, lacking social support, sex, stage, or Karnofsky performance score are associated with EF at t3. CONCLUSIONS: Exhaustion, head and neck discomfort, and body image concerns emerged as modifiable factors that predict future impaired EF in patients with DTC undergoing treatment. These factors could be targeted in prehabilitation, rehabilitation or other interventional programs to potentially improve or preserve patients' EF.

Authors

Institutions

Publication Details

Journal
Thyroid
Published
2026-04-13
DOI
https://doi.org/10.1177/10507256261442504
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Prospective Predictors of Poor Emotional Functioning in Patients with Differentiated Thyroid Carcinoma

Olga Husson, Harald Rimmele, Juan Ignacio Arrarás, Ricardo Ribeiro Gama et al.
Thyroid
Thyroid Cancer Diagnosis and Treatment
article

Prospective Predictors of Poor Emotional Functioning in Patients with Differentiated Thyroid Carcinoma

Olga Husson, Harald Rimmele, Juan Ignacio Arrarás, Ricardo Ribeiro Gama, Gerasimos P. Sykiotis, Giuseppe Fanetti, Naomi Kiyota, Guy Andry, Rita Canotilho, Ιoannis Iakovou, Eva Hammerlid, Arild Andrè Østhus, Matthias Buettner, Eva‐Maria Gamper, Johanna Inhestern, Athina Mageiropoulou, Laura Deborah Locati, Akram Al-Ibraheem, Susanne Singer, Georgios Ioannidis, Monica Pinto
article en

Abstract

BACKGROUND: The health-related quality of life (HRQoL) of patients with differentiated thyroid carcinoma (DTC), especially their mental health, can be compromised by various factors beyond disease prognosis and treatment stage. However, predictors of poor emotional functioning (EF) in DTC patients have not been thoroughly studied. To inform targeted interventions that could improve or preserve HRQoL in patients with DTC, this study aimed to identify predictors of impaired EF, and particularly modifiable factors. METHODS: = 196) were assessed at three timepoints before treatment (t1), 6 weeks after the start of treatment (t2), and 6 months after t2 (t3). Multilevel, multivariable logistic regression models were used to assess the likelihood of impaired EF at t3 according to predefined potential predictors at t1 and t2. RESULTS: = 0.001) per score point, respectively. There was no evidence that worry about important others, lacking social support, sex, stage, or Karnofsky performance score are associated with EF at t3. CONCLUSIONS: Exhaustion, head and neck discomfort, and body image concerns emerged as modifiable factors that predict future impaired EF in patients with DTC undergoing treatment. These factors could be targeted in prehabilitation, rehabilitation or other interventional programs to potentially improve or preserve patients' EF.

Thyroid
Oslo University Hospital (NO), Universität Innsbruck (AT), Johannes Gutenberg University Mainz (DE), Aristotle University of Thessaloniki (GR), University of Pavia (IT), King Hussein Cancer Center (JO), Nicosia General Hospital (CY), Sahlgrenska University Hospital (SE), Institut Jules Bordet (BE), Erasmus MC (NL), The Netherlands Cancer Institute (NL), Kobe University Hospital (JP), Istituti Clinici Scientifici Maugeri (IT), Hospital de Câncer de Barretos (BR), Complejo Hospitalario de Navarra (ES), Bundesverband Glaukom-Selbsthilfe (DE), IPO Porto (PT), Rostock University of Music and Theatre (DE), Centro di Riferimento Oncologico (IT), Jena University Hospital (DE), Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), University Medical Centre Mannheim (DE), University of Rostock (DE), University of Gothenburg (SE), University of Lausanne (CH)
European Organisation for Research and Treatment of Cancer
No poverty
Openalex Percentile: Top 30%
Thyroid Cancer Diagnosis and Treatment
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.