Relative circadian disruption in urinary excretion associates with renal function in biopsy-proven primary glomerular diseases: a cross-sectional study using the novel CRDI metric
from 0.748 to 0.800 and yielded a significant net reclassification improvement (NRI = 0.237). The CRDI effectively quantifies relative circadian disruption. CRDI_cr is independently associated with renal function in a pathology-specific manner, highlighting its potential as a novel biomarker for refined risk stratification in specific glomerular diseases, particularly IgA nephropathy.
Authors
- Xinping Xu (ORCID: https://orcid.org/0000-0002-9568-4171)
- Yong Li (ORCID: https://orcid.org/0000-0003-4038-0493)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Guangyan Cai
Institutions
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2026-04-12
- DOI
- https://doi.org/10.1080/0886022x.2026.2649022
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- General Hospital of People’s Liberation Army
- National Key Research and Development Program of China