Plant Vacuolar and Human Endolysosomal Two-Pore Channels: Similarities and Differences
-mobilizing messenger NAADP, likely through interaction with an accessory protein. Functionally, human TPCs are involved in endolysosomal trafficking, membrane fusion, and intracellular signaling, with emerging roles in immunity, metabolism, and disease. Overall, TPCs represent key components of intracellular ion homeostasis and cellular physiology; however, their precise regulatory mechanisms and integrated physiological roles remain only partially understood and, in several respects, are still elusive.
Authors
- Matteo Ceccarelli (ORCID: https://orcid.org/0000-0003-4272-902X)
- Stefan Milenkovic (ORCID: https://orcid.org/0000-0002-1327-3564)
- Laura Lagostena (ORCID: https://orcid.org/0000-0001-6440-3720)
- Armando Carpaneto (ORCID: https://orcid.org/0000-0002-5060-3657)
- Petra Dietrich (ORCID: https://orcid.org/0000-0002-9209-8089)
- Antonella Gradogna (ORCID: https://orcid.org/0000-0002-4401-9913)
- Margherita Festa (ORCID: https://orcid.org/0000-0003-4990-7554)
- Antonio Filippini (ORCID: https://orcid.org/0000-0001-8453-287X)
- Emanuel Franco
- MARTINA MEUCCI
Institutions
- University of Cagliari (IT)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- National Research Council (IT)
- University of Genoa (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Cells
- Published
- 2026-04-11
- DOI
- https://doi.org/10.3390/cells15080675
- Primary Topic
- Calcium signaling and nucleotide metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00